Toxicity and quality of life data from the PROFILE1014 trial
Source:R/data.R
profile1014_toxicity.RdThis dataset contains simulated toxicity data and quality of life (QoL) scores
from the PROFILE 1014 randomized clinical trial (crizotinib versus chemotherapy
in ALK+ non–small cell lung cancer). It includes both any‑grade (G1–4) and
severe (G3–4) adverse events. Patient‑reported QoL scores are stored in the
qol column. The dataset provides the number of patients per trial arm.
Please refer to the accompanying documentation or vignette for details on how
QoL scores are defined and interpreted.
Format
A data frame with X rows and Y variables:
- EventName
Name of the adverse event.
- SystemOrganClass
System organ class for the adverse event.
- Incidence_G1_4_Control
Incidence (%) of any‑grade (G1–4) toxicity in the control arm.
- Incidence_G1_4_Experimental
Incidence (%) of any‑grade (G1–4) toxicity in the experimental arm.
- Incidence_G3_4_Control
Incidence (%) of severe (G3–4) toxicity in the control arm.
- Incidence_G3_4_Experimental
Incidence (%) of severe (G3–4) toxicity in the experimental arm.
- qol
Numeric QoL score associated with each adverse event.
- N_patients
Named numeric vector with the number of patients per trial arm.